Fixed-time observer-based distributed secondary voltage and frequency control of islanded AC microgrids

This paper deals with the problem of voltage and frequency control of distributed generators (DGs) in AC islanded microgrids. The main motivation of this work is to obviate the shortcomings of conventional centralized and distributed control of micro-grids by providing a better alternative control strategy with better control performance than state-of-the art approaches. A distributed secondary control protocol based on a novel fixed-time observer-based feedback control method is designed for fixed-time frequency and voltage reference tracking and disturbance rejection. Compared to the existing secondary microgrid controllers, the proposed control strategy ensures frequency and voltage reference tracking and disturbance rejection before the desired fixed-time despite the microgrid initial conditions, parameters uncertainties and the unknown disturbances. Also, the controllers design and tuning is simple, straightfor-ward and model-free.i.e, the knowledge of the microgrid parameters, topology, loads or transmission lines impedance are not needed in the design procedure. The use of distributed control approach enhances the reliability of the system by making the control system geographically distributed along with the power sources, by using the neighboring DGs informations instead of the DG’s local informations only and by cooperatively rejecting external disturbances and maintaining the frequency and the voltage at their reference values at any point of the microgrid. The efficiency of the proposed approach is verified by comparing its performance in reference tracking and its robustness to load power variations to some of the works in literature that addressed distributed secondary voltage and frequency control

Adaptive Observer with Enhanced Gain to Address Deficient Excitation

International audienceFor joint estimation of state variables and unknown parameters, adaptive observers usually assume some persistent excitation (PE) condition. In practice, the PE condition may not be satised, because the underlying recursive estimation problem is ill-posed. To remedy the lack of PE condition, inspired by the ridge regression, this paper proposes a regularized adaptive observer with enhanced parameter adaptation gain. Like in typical ill-posed inverse problems,regularization implies an estimation bias, which can be reduced by using prior knowledge aboutthe unknown parameters

Regularized Adaptive Observer to Address Deficient Excitation

International audienceAdaptive observers are recursive algorithms for joint estimation of both state variables and unknown parameters. Usually some persistent excitation (PE) condition is required for the convergence of adaptive observers. However, in practice, it may happen that the PE condition is not satisfied, because the available sensor signals do not contain sufficient information for the considered recursive estimation problem, which is ill-posed. To remedy the lack of PE condition, inspired by typical methods for solving ill-posed inverse problems, this paper proposes a regularized adaptive observer for general linear time varying (LTV) systems. Two regularization terms are introduced in both state and parameter estimation recursions, in order to preserve the state-parameter decoupling transformation involved in the design of the adaptive observer. Like in typical ill-posed inverse problems, regularization implies an estimation bias, which can be reduced by using prior knowledge about the unknown parameters

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries